Inter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response

ABSTRACT: Glucocorticoids (GCs) are steroid hormones widely used as pharmaceutical interventions, which act mainly by regulating gene expression levels. A large fraction of patients (~30%), especially those of African descent, show a weak response to treatment. To interrogate the contribution of variable transcriptional response to inter-ethnic differences, we measured in vitro lymphocyte GC sensitivity (LGS) and transcriptome-wide response to GCs in peripheral blood mononuclear cells (PBMCs) from African-American and European-American healthy donors. We found that transcriptional response after 8hrs treatment was significantly correlated with variation in LGS within and between populations. We found that NFKB1, a gene previously found to predict LGS within populations, was more strongly downregu

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Maranville 

PROVIDER: E-GEOD-33649 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress