Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Fetal programming of muscle transcriptome in response to gestational dietary protein levels in the pig [LP]

ABSTRACT: German landrace gilts were fed a low protein diet (LP, 6% CP) throughout their whole pregnancy. Subsequently muscle transcriptome profiles of the offspring were analysed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn) per stage offspring of 3 gilts were collected for expression profiling

ORGANISM(S): Sus scrofa

SUBMITTER: Klaus Wimmers 

PROVIDER: E-GEOD-33739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional response of skeletal muscle to a low-protein gestation diet in porcine offspring accumulates in growth- and cell cycle-regulating pathways.

Oster Michael M   Murani Eduard E   Metges Cornelia C CC   Ponsuksili Siriluck S   Wimmers Klaus K  

Physiological genomics 20120703 16

Inadequate maternal protein supply during gestation represents an environmental factor that affects physiological signaling pathways with long-term consequences for growth, function, and structure of various tissues. Hypothesizing that the offspring's transcriptome is persistently altered by maternal diets, we used a porcine model to monitor the longitudinal expression changes in muscle to identify pathways relevant to fetal initiation of postnatal growth and development. German Landrace gilts w  ...[more]

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