The Human Oviductal Transcriptome Reveals An Anti-inflammatory, Anti-angiogenic, Secretory and Matrix-stable Environment During Embryo Transit

ABSTRACT: Human oviduct serves as a conduit for sperm in the peri-ovulatory phase and to nurture and facilitate transport of the developing embryo en route to the uterus for subsequent nidation during the luteal phase of the cycle. Interactions between the embryo and oviductal epithelial surface proteins and secreted products during the four day embryo transit are largely undefined. Herein, we have investigated gene expression in human oviduct in the early luteal vs. follicular phase to identify candidate genes and biomolecular processes that may participate in maturation and transport of the embryo as it traverses this tissue. Oviductal RNA was isolated, processed, and hybridized to oligonucleotide arrays. Resulting data were analyzed by bioinformatic approaches and revealed that 650 genes were sig

ORGANISM(S): Homo sapiens

SUBMITTER: Linda Giudice 

PROVIDER: E-GEOD-33805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress