Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis

ABSTRACT: Pathogenesis and factors for determining progression of alcoholic and non-alcoholic steatosis to steatohepatitis with risk of further progression to liver cirrhosis and cancer are poorly understood. In the present study, we aimed to identify potential molecular signatures for discrimination of steatohepatitis from steatosis. Global gene expression analysis was applied to unravel differentially expressed genes between steatohepatitis compared to steatosis and control samples. For functional annotation as well as the identification of disease-relevant biological processes of the differentially expressed genes the gene ontology (GO) database was used. Genes down-regulated in steatohepatitis were mainly involved in metabolic processes. Genes up-regulated in steatohepatitis samples were associa

ORGANISM(S): Homo sapiens

SUBMITTER: Julia Starmann 

PROVIDER: E-GEOD-33814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress