Genome-wide transcriptional responses to benzo[a]pyrene and clofibrate in the tunicate Oikopleura dioica

ABSTRACT: Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics are not known in most invertebrates. Here, using high density tiling arrays with over 2 million probes, we explored genome-wide gene expression in the tunicate Oikopleura dioica in response to two model xenobiotic chemicals – the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) the pharmaceutical compound Clofibrate (Clo). The genotoxic compound BaP induced xenobiotic biotransformation and oxidative stress responsive genes, as in vertebrates. Notable exceptions were genes of the aryl hydrocarbon receptor (AhR) signaling pathway. C

ORGANISM(S): Oikopleura dioica

SUBMITTER: Fekadu Yadetie 

PROVIDER: E-GEOD-33818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress