X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription

ABSTRACT: Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate the mechanism, we perform allele-specific ChIP-seq for chromatin epitopes and analyze RNA-seq data (SRA010053). The hypertranscribed Xa demonstrates enrichment of active chromatin marks relative to autosomes. We derive predictive models for relationships among Pol II, active mark densities and gene expression, and we suggest that Xa upregulation involves increased transcription initiation and elongation. Enrichment of active marks on Xa does not scale proportionally with transcription output, a d

ORGANISM(S): Mus musculus

SUBMITTER: Ruslan Sadreyev 

PROVIDER: E-GEOD-33823 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress