Dataset Information
Dysregulation of c-terminal ezrin phosphorylation prevents tumor progression and metastasis and alters cellular metabolism in osteosarcoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chand Khanna
PROVIDER: E-GEOD-33897 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.
Cancer research 20111206 4
Ezrin links the plasma membrane to the actin cytoskeleton where it plays a pivotal role in the metastatic progression of several human cancers; however, the precise mechanistic basis for its role remains unknown. Here, we define transitions between active (phosphorylated open) and inactive (dephosphorylated closed) forms of Ezrin that occur during metastatic progression in osteosarcoma. In our evaluation of these conformations we expressed C-terminal mutant forms of Ezrin that are open (phosphom ...[more]
