The Role of the E2F1 transcription factor in the innate immune response to systemic LPS [mRNA]

ABSTRACT: Our recent study of gene expression in mice treated with LPS systemically identified the E2F1 transcription factor as a novel regulator of innate immune response in lung, liver, and spleen tissue. Our follow up studies showed that RNAi-mediated inhibition or E2F1 gene deficiency lead to reduced inflammatory response to LPS in vitro and in vivo. Furthermore, a clear role for the role of miRNAs in the regulation of innate immune response to LPS has emerged. In the current study, we further examined B6;129E2F1-/- and B6x126 F2 mice in the systemic LPS model and used gene expression profiling to identify a defect in the coagulation cascade that contributes to increased morbidity of B6;129E2F1-/- mice despite their reduced systemic inflammatory response. We also studied miRNA expression profil

ORGANISM(S): Mus musculus

SUBMITTER: David McKean 

PROVIDER: E-GEOD-33901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress