Gene expression in the blood of SIV infected Rhesus macaques following in vivo PD-1 blockade

ABSTRACT: Hyperimmune activation is one of the strong predictors of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I interferon (IFN) signaling. Combination antiretroviral therapy suppresses hyperimmune activation only partially in HIV-infected individuals. Here, we show that blockade of Programmed Death-1 (PD-1) during chonic SIV infection significantly reduces the expression of transcripts associated with type I IFN signaling in the blood and colorectal tissue of rhesus macaques (RM). The effect of PD-1 blockade on type I IFN signaling was durable and persisted under high viremia, a condition that is seen in nonprogressive SIV infection in their natural hosts. The reduced type I IFN signaling was associated with enhanced expression

ORGANISM(S): Macaca mulatta

SUBMITTER: RAVI DYAVAR SHETTY 

PROVIDER: E-GEOD-33933 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress