Dataset Information
Role of PKD2 in TCR-induced transcriptional reprogramming of naïve T cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Maria Navarro
PROVIDER: E-GEOD-33942 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
The Biochemical journal 20120301 3
PKD (protein kinase D) 2 is a serine/threonine kinase activated by diacylglycerol in response to engagement of antigen receptors in lymphocytes. To explore PKD2 regulation and function in TCR (T-cell antigen receptor) signal transduction we expressed TCR complexes with fixed affinity for self antigens in the T-cells of PKD2-null mice or mice deficient in PKD2 catalytic activity. We also developed a single cell assay to quantify PKD2 activation as T-cells respond to developmental stimuli or engag ...[more]
