MondoA is highly expressed in acute lymphoblastic leukemia and modulates metabolism, differentiation and survival

ABSTRACT: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted treatment of childhood ALL, we performed a comprehensive transcriptome analysis yielding a set of genes specifically overexpressed in ALL. Among them we identified MondoA - a transcription factor regulating glycolysis in response to glucose availability. Here, we confirm that MondoA is highly overexpressed ALL, whereas the MondoA paralog, MondoB, is not expressed. Expression studies revealed that MondoA is not regulated by glucose availability in leukemia cells, but by the presence of lactate. An in silico MondoA promoter analysis identified two methylation-prone CpG-islands and four conserved binding sites for runt-related transcription factor 1 (RUNX1). In fact, MondoA and

ORGANISM(S): Homo sapiens

SUBMITTER: Olivia Prazeres da Costa 

PROVIDER: E-GEOD-33967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress