Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lu Cui
PROVIDER: E-GEOD-34002 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of clinical investigation 20130325 4
Tumor formation constitutes a major obstacle to the clinical application of embryonic stem cell-derived (ESC-derived) cells. In an attempt to find major extracellular signaling and intrinsic factors controlling tumorigenicity and therapeutic functionality of transplanted ESC-derived retinal progenitor cells (ESC-RPCs), we evaluated multiple kinds of ESC-RPCs in a mouse retinal degeneration model and conducted genome-wide gene expression profiling. We identified canonical WNT signaling as a criti ...[more]