Integral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [ChIP_seq]

ABSTRACT: The circadian clock acts at the genomic level to coordinate internal behavioral and physiologic rhythms via the CLOCK-BMAL transcriptional heterodimer. Although the nuclear receptors REV-ERBα and β have been proposed to contribute to clock function, their precise roles and importance remain unresolved. To establish their regulatory potential we generated comparative cistromes of both Rev-erb isoforms, which revealed shared recognition at over ~50% of their total sites and extensive overlap with the master clock regulator Bmal. While Rev-erbα has been shown to directly regulate Bmal expression, the cistromic analysis reveals a more profound connection between Bmal and Rev-erbα and β regulatory circuits than previously suspected. Genes within the intersection of the Bmal and Rev-erb cistr

ORGANISM(S): Mus musculus

SUBMITTER: Ruth Yu 

PROVIDER: E-GEOD-34019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress