Loss of DNA methylation affects recombination landscape in Arabidopsis

ABSTRACT: During sexual reproduction half of the genetic material is deposited in gametes and a complete set of chromosomes is restored upon fertilisation. Reduction of the genetic information prior gametogenesis occurs in meiosis where crossovers (COs) between homologous chromosomes secure an exchange of their genetic information. COs are not evenly distributed along chromosomes and are suppressed in chromosomal regions encompassing compact, hypermethylated centromeric and pericentromeric DNA. Therefore, it has been postulated that DNA hypermethylation is inhibitory to COs. Here by analysing meiotic recombination in mutant plants with hypomethylated DNA we observed unexpected and counterintuitive effects of the DNA methylation losses on COs distribution, further promoting recombination in the natur

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Etienne Bucher 

PROVIDER: E-GEOD-34173 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress