Transcriptome profiles comparison between the B220+, CD27- and CD27+ NK cell subset

ABSTRACT: The cell lineage origin of interferon-producing killer dendritic cells (IKDC), which exhibit prominent anti-tumoral activity, has been subject to debate. Although IKDC were first described as a cell type exhibiting both pDC and NK cell properties, the current view reflects that IKDC merely represent activated NK cells expressing B220, which were thus renamed B220+ NK cells. Herein, we further investigate the lineage relationship of B220+ NK cells with regards to other NK cell subsets. We surprisingly find that, upon adoptive transfer, B220- NK cells did not acquire B220 expression, even in the presence of potent activating stimuli. These findings strongly argue against the concept that B220+ NK cells are activated NK cells in vivo. Moreover, we unequivocally demonstrate that B220+ NK cells

ORGANISM(S): Mus musculus

SUBMITTER: Sylvie Lesage 

PROVIDER: E-GEOD-34237 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress