Candida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway

ABSTRACT: Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induced functional programming of monocytes, leading to enhanced cytokine production in vivo and in vitro. The training required the beta glucan receptor dectin 1 and the non-canonical Raf 1 pathway. Monocyte training by beta-glucans was mediated by epigenetic mechanisms through genome-wide changes in histone trimethylation at H3K4. Pathway analysis showed specific induction of epigenetic changes in genes of innate immunity. The functional programming of monocytes, reminiscent of similar properties o

ORGANISM(S): Homo sapiens

SUBMITTER: H. Stunnenberg 

PROVIDER: E-GEOD-34260 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress