Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology

ABSTRACT: BACKGROUND: Following fine needle aspiration, 15-30% of thyroid nodules are not clearly benign or malignant. These cytologically indeterminate nodules are often referred for diagnostic surgery, though most prove benign. A novel diagnostic test measuring the expression of 167 genes has shown promise in improving pre-operative risk assessment. We evaluated this test in a prospective, multicenter study. METHODS: Over 19 months, we performed a prospective study at 49 clinical sites enrolling 3,789 patients and collecting 4,812 samples from thyroid nodules >1cm requiring evaluation. We obtained 577 cytologically indeterminate aspirates with corresponding histopathology of excised lesions on 413. Central blinded histopathologic review served as the reference (“gold”) standard. After applying in

ORGANISM(S): Homo sapiens

SUBMITTER: James Diggans 

PROVIDER: E-GEOD-34289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress