Transcription profiling of hearts from mice treated with aldosterone for different time duration to study the genetic mechanism of aldosterones direct adverse effects on the heart.

ABSTRACT: Aldosterone is known to have a number of direct adverse effects on the heart, including fibrosis and myocardial inflammation. However, genetic mechanisms of aldosterone action on the heart remain unclear. This experiment investigated of temporal changes in gene expression profile of the whole heart induced by acute administration of a physiologic dose of aldosterone in the mouse. mRNA levels of 34,000 known mouse genes were measured at eight time points after aldosterone administration using oligonucleotide microarrays and compared to those of the control animals who underwent a sham injection. A novel software tool (CAGED) designed for analysis of temporal microarray experiments using a Bayesian approach was used to identify genes differentially expressed between the aldosterone-injected

ORGANISM(S): Mus musculus

SUBMITTER: Alexander Turchin 

PROVIDER: E-GEOD-3440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress