Gene expression pattern in Caco-2 cells following rotavirus infection

ABSTRACT: Rotaviruses are recognized as the leading cause of severe dehydrating diarrhea in infants and young children worldwide. Preventive and therapeutic strategies are urgently needed to fight this pathogen. In tissue culture and in vivo, rotavirus induces structural and functional alterations in the host cell. In order to better understand the molecular mechanisms involved in the events after rotavirus infection, we identified host cellular genes whose mRNA levels changed after infection. For this analysis, we used microarrays containing more than 38,000 human cDNAs to study the transcriptional response of the human intestinal cell line Caco-2 to rotavirus infection. We found that 508 genes were differentially regulated >2-fold at 16 h after rotavirus infection, and only one gene was similarly

ORGANISM(S): Homo sapiens

SUBMITTER: Dino Feigelstock 

PROVIDER: E-GEOD-3442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress