Differential Response Following Spinal Cord Injury in EphA4 Knockout

ABSTRACT: Mice lacking the developmental axon guidance molecule EphA4 have previously been shown to exhibit extensive axonal regeneration and functional recovery following spinal cord injury. To assess mechanisms by which EphA4 may modify the response to neural injury, a microarray was performed on spinal cord tissue from mice with spinal cord injury and sham injured controls. RNA was purified from spinal cords of adult EphA4 knockout and wild-type mice four days following lumbar spinal cord hemisection or laminectomy only and was hybridised to Affymetrix All-Exon Array 1.0 GeneChips. While subsequent analyses indicated that several pathways were altered in EphA4 knockout mice, of particular interest was the attenuated or otherwise altered expression of a number of inflammatory genes, including Ar

ORGANISM(S): Mus musculus

SUBMITTER: Victoria Perreau 

PROVIDER: E-GEOD-34430 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress