Cooperativity of Rb, Brca1, and p53 and malignant breast cancer evolution

ABSTRACT: The dire need for more effective treatments for clinically aggressive breast cancers has motivated intensive investigations into their cellular and molecular etiology. Breast cancers that are “triple-negative” for the clinical markers, ESR1, PGR, and HER2, typically belong to the Basal-like molecular subtype. Defective Rb, p53, and Brca1 pathways are each associated with triple-negative and Basal-like subtypes. Our mouse genetic studies demonstrate that concomitant inactivation of all three pathways in mammary epithelium has an additive effect on tumor latency, and predisposes highly penetrant, metastatic, adenocarcinomas. These tumors are poorly differentiated with histologic features that are common among human Brca1-mutated tumors, including heterogeneous morphology, metaplasia, and nec

ORGANISM(S): Mus musculus

SUBMITTER: Karl Simin 

PROVIDER: E-GEOD-34479 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress