Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo

ABSTRACT: Background: The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT). Methods: We used xenograft models of human cancer cells in immunocompromised mice, profiling the harvested tumors separately with species-specific probes and computationally analyzing the results. Results: Here we show that human cancer cells express in vivo a precise multi-cancer invasion-associated gene expression signature that prominently includes many EMT markers, among them the transcription factor Slug, fibronectin, and α-SMA. We found that human, but not mouse, cells express the signature and Slug is the only upregulated EMT-inducing transcription factor. The signature is a

ORGANISM(S): Homo sapiens

SUBMITTER: Dimitris Anastassiou 

PROVIDER: E-GEOD-34481 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress