DNA methylation regulates lineage-specifying genes in the human vascular system [methylation array].

ABSTRACT: During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between the two endothelial cell types have been reported. Since changes in phenotypic plasticity and cellular differentiation processes frequently involve epigenetic mechanisms, we wondered whether DNA methylation might play a role in regulating cell type-specific expression in endothelial cells. By analyzing global gene expression and methylation patterns of primary human dermal lymphatic and blood endothelial cells, we identified a highly significant set of genes, which were different

ORGANISM(S): Homo sapiens

SUBMITTER: Silvia Rueberg 

PROVIDER: E-GEOD-34486 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress