PiRNA-mediated transgenerational inheritance of an acquired trait

ABSTRACT: The maintenance of genome integrity is an essential trait to the successful transmission of genetic information. In animal germ cells, piRNAs guide PIWI proteins to silence transposable elements (TEs) in order to maintain genome integrity. In insects, most of TE silencing in the germline is achieved by secondary piRNAs that are produced by a feed-forward loop (the ping-pong cycle), which requires the piRNA-directed cleavages of two types of RNAs: mRNAs of functional euchromatic TEs and heterochromatic transcripts that contain defective TE sequences. The first cleavage which initiates such amplification loop remains poorly understood. Taking advantage of the existence of strains that are devoid of functional copies of the LINE-like I-element, we report that in such Drosophila ovaries, the

ORGANISM(S): Drosophila melanogaster

SUBMITTER: SEVERINE CHAMBEYRON 

PROVIDER: E-GEOD-34506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress