Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of olfactory epithelium isolated from wild type and SR-A mutant mice at different time points after bilateral olfactory bulbectomy to understand the temporal gene expression patterns.

ABSTRACT: Sham and bilateral OBX were performed on wild-type and SR-A mutant mice. Tissue collected 2, 8, 16, and 48 hours following OBX. Expression profiles were determined using Affynetrix MG U74Av2 chips. Experiment Overall Design: olfactory epithelium from 3 wild type 6 week old mice and 3 SR-A 6 week old mutant mice

ORGANISM(S): Mus musculus

SUBMITTER: Marilyn Getchell 

PROVIDER: E-GEOD-3455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Temporal gene expression profiles of target-ablated olfactory epithelium in mice with disrupted expression of scavenger receptor A: impact on macrophages.

Getchell M L ML   Li H H   Vaishnav R A RA   Borders A S AS   Witta J J   Subhedar N N   de Villiers W W   Stromberg A J AJ   Getchell T V TV  

Physiological genomics 20060801 3

Target ablation [removal of the olfactory bulb (OBX)] induces apoptotic death of olfactory sensory neurons (OSNs) and an immune response in which activation and recruitment of macrophages (ms) into the olfactory epithelium (OE) occupy a central role. Ms phagocytose apoptotic neurons and secrete cytokines/growth factors that regulate subsequent progenitor cell proliferation and neurogenesis. Scavenger receptor A (SR-A) is a pattern recognition receptor that mediates binding of ms to apoptotic cel  ...[more]

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