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Expression data from mouse kidney tissue

ABSTRACT: The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT1 antagonism ameliorate renal damage. This is a comparison between the renin inhibitor aliskiren with the At1 antagonist losartan in mice with chronic kidney disease due to renal ablation. Renal tissue from ablated mice was used after 6-week treatment with either 500 mg/l losartan or 50 mg/kg aliskiren per day (n = 5)

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Streichert

PROVIDER: E-GEOD-34552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.

Fraune Christoph C Lange Sascha S Krebs Christian C Hölzel Alexandra A Baucke Jana J Divac Nevena N Schwedhelm Edzard E Streichert Thomas T Velden Joachim J Garrelds Ingrid M IM Danser A H Jan AH Frenay Anne-Roos AR van Goor Harry H Jankowski Vera V Stahl Rolf R Nguyen Genevieve G Wenzel Ulrich Otto UO

American journal of physiology. Renal physiology 20120711 7

The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT(1) antagonism ameliorate renal damage. However, it is unclear which mechanism exerts better nephroprotection. We compared the renin inhibitor aliskiren with the AT(1) antagonist losartan in mice with chronic kidney disease due to renal ablation. Doses were adjusted to equipotent inhibition of the renin-angiotensin s ...[more]

PMID: 22791343

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Expression data from mouse kidney tissue

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