A novel preclinical mouse model of spontaneous breast cancer metastasis

ABSTRACT: Metastatic disease remains one of the most urgent clinical challenges accounting for over 90% of cancer-related deaths. Yet, the identification of novel therapeutic targets to fight or prevent metastatic disease has been hampered by the limited availability of clinically relevant mouse models of metastasis formation. To address this caveat, we developed a novel preclinical mouse model of spontaneous metastatic breast cancer that recapitulates the key biological events of the metastatic cascade and mimics the clinical course of metastatic disease in humans. Exploiting the conditional K14cre;CdhF/F;Trp53F/F mouse model of de novo mammary tumor formation, we orthotopically transplanted K14cre;CdhF/F;Trp53F/F derived mouse invasive lobular carcinoma (mILC) fragments into mammary glands of wild

ORGANISM(S): Mus musculus

SUBMITTER: Chris Doornebal 

PROVIDER: E-GEOD-34666 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress