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Effects of Ars2 or DGCR8 siRNA on microRNA expression

ABSTRACT: Ars2 is a component of the nuclear cap-binding complex that is required for cellular proliferation and contributes to microRNA biogenesis. Arrays were performed to determine the repertoire of microRNAs that change following knock-down of Ars2. Knock-down of DGCR8 was also performed to determine which microRNAs were expressed and had half-lives short enough to significantly decrease over the duration of the experiment. 9 samples were analyzed including: three biological replicates of control siRNA-transfected HeLa cells, HeLa cells transfected with three independent siRNAs targeting Ars2, or HeLa cells transfected with three independent siRNAs targeting DGCR8.

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Olejniczak

PROVIDER: E-GEOD-34680 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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