MicroRNA expression in HMVECs: control vs. VEGF-treated vs. PEDF/VEGF-treated

ABSTRACT: MicroRNA expression profiling of human microvascular endothelial cells (HMVECs) treated with either vascular endothelial growth factor (VEGF) only or in combination with the natural angiogenesis inhibitor pigment epithelial-derived factor (PEDF). Originally we were interested in the microRNA-mediated regulation of angiogenesis by the endogenous anti-angiogenic PEDF. To identify the microRNAs involved in PEDF signaling in activated endothelial cells, we compared the levels of microRNAs in non-treated microvascular endothelial cells, cells treated with VEGF, and cells treated with a combination of VEGF and PEDF. After treatment, total RNA content was isolated and sent for analysis to LC Sciences, LLC. They performed expression profiling and completed statistical analysis, based on which we

ORGANISM(S): Homo sapiens

SUBMITTER: Dauren Biyashev 

PROVIDER: E-GEOD-34735 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress