Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Human Tax transfected HeLa cell

ABSTRACT: Human T cell leukemia virus type 1 (HTLV-1) Tax is potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. In this study, a large-scale host cell signaling events related to cellular proliferation were used to identify genes involved in Tax-mediated cell signaling events related to cellular proliferation and apoptosis. HeLa cell transiently transfected with with pCAGGS vector for control sample was compared with HeLa cell transiently transfected with with pCAGGS-Tax-FLAG vector. These cells were incubated for 30h after transfection and were used for total RNA isolation.

ORGANISM(S): Homo sapiens

SUBMITTER: Yoko Aida 

PROVIDER: E-GEOD-34750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis.

Arainga Mariluz M   Murakami Hironobu H   Aida Yoko Y  

BMC genomics 20120622

<h4>Background</h4>Human T cell leukemia virus type 1 (HTLV-1) Tax is a potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. Many reports show that Tax is capable of regulating cell cycle progression and apoptosis both positively and negatively. However, it still remains to understand why the Tax oncoprotein induces cell cycle arrest and apoptosis, or whether Tax-induced apoptosis is dependent upon its ability to induce G1 arrest. The present  ...[more]

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