Gene expression profiling of myelin-phagocytosing macrophages

ABSTRACT: Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system in which macrophages and microglia play a central role. During active multiple sclerosis foamy macrophages and microglia, containing degenerated myelin, are abundantly found in demyelinated areas. Recent studies have described an altered macrophage phenotype after myelin internalization. However, by which mechanisms myelin affects the phenotype of macrophages and how this phenotype can influence lesion progression is unclear. Here we demonstrate, by using genome wide gene expression analysis, that myelin-phagocytosing macrophages have an enhanced expression of genes in pathways involved in migration, phagocytosis and inflammation. More interestingly, we show that myelin internalization induce

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jeroen Bogie 

PROVIDER: E-GEOD-34811 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress