Dataset Information
Transcription profiling of mouse tendon, cornea, and skin fibroblasts stimulated with mechanical stress to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Steve Winder
PROVIDER: E-GEOD-3486 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin.
The Biochemical journal 20060601 2
Primary fibroblasts isolated from foetal mouse cornea, skin and tendon were subjected to linear shear stress and analysed for morphological parameters and by microarray, as compared with unstimulated controls. Approx. 350 genes were either up- or down-regulated by a significant amount, with 51 of these being common to all three cell types. Approx. 50% of altered genes in tendon and cornea fibroblasts were changed in common with one of the other cell types, with the remaining approx. 50% being sp ...[more]
