Dysregulated deltaNp63alpha negatively regulates p73-mediated maspin expression

ABSTRACT: The p53 homologue, p63, is critical for normal epidermal development. While overexpression of deltaNp63alpha has been reported in squamous cell cancers, the contribution of p63 to cancer pathogenesis remains unclear. We previously demonstrated that overexpressed deltaNp63alpha aberrantly maintains proliferation of primary epidermal keratinocytes under conditions that normally induce growth arrest and differentiation. To identify target genes impacted by dysregulated deltaNp63alpha that may contribute to squamous cancer development and progression, microarray analyses were performed. Herein we report that elevated deltaNp63alpha differentially regulates genes in primary mouse keratinocytes involved in a variety of cellular functions, including cell cycle regulation, differentiation, skin ba

ORGANISM(S): Mus musculus

SUBMITTER: Kathryn King 

PROVIDER: E-GEOD-34862 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress