Microarray analysis to identify Egfr-responsive genes

ABSTRACT: The highly conserved Epidermal Growth Factor-receptor (Egfr) pathway is required in all animals for normal development and homeostasis; consequently, aberrant Egfr signaling is implicated in a number of diseases. Genetic analysis of Drosophila melanogaster Egfr has contributed significantly to understanding this conserved pathway and has led to the discovery of new components and targets. Here we used microarray analysis of Drosophila third instar wing discs, in which Egfr signaling was perturbed, to identify new Egfr-responsive genes. Upregulated transcripts included five known targets suggesting the approach was valid. We investigated the function of 29 previously uncharacterized genes, which had pronounced responses. The Egfr pathway is important for wing-vein patterning and using reve

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Amanda Simcox 

PROVIDER: E-GEOD-34872 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress