Characterization of T-rapamycin cells by gene expression profiling
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Luciano Castiello
PROVIDER: E-GEOD-34911 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential gene expression profile of first-generation and second-generation rapamycin-resistant allogeneic T cells.
Castiello Luciano L Mossoba Miriam M Viterbo Antonella A Sabatino Marianna M Fellowes Vicki V Foley Jason E JE Winterton Matthew M Halverson David C DC Civini Sara S Jin Ping P Fowler Daniel H DH Stroncek David F DF
Cytotherapy 20130124 5
<h4>Background aims</h4>We completed a phase II clinical trial evaluating rapamycin-resistant allogeneic T cells (T-rapa) and now have evaluated a T-rapa product manufactured in 6 days (T-rapa(6)) rather than 12 days (T-Rapa(12)).<h4>Methods</h4>Using gene expression microarrays, we addressed our hypothesis that the two products would express a similar phenotype. The products had similar phenotypes using conventional comparison methods of cytokine secretion and surface markers.<h4>Results</h4>Un ...[more]
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