Expression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML

ABSTRACT: We evaluated gene expression changes in murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of homozygous conditional alleles for Ezh2 or Eed, both of which are components of the Polycomb Repressive Complex2. For WT cells, 3 biological replicates were hybridized. For Ezh2-null cells, 4 biological replicates were hybridized. For Eed-cells, 3 biological replicates were hybridized.

ORGANISM(S): Mus musculus

SUBMITTER: Amit Sinha 

PROVIDER: E-GEOD-34959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress