Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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CcpA Chromatin immunoprecipitation on chip of JIR8094 (CD630E) WT strain and a ccpA mutant after 6h of growth in TY

ABSTRACT: Comparison of ccpA Chromatine immunoprecipitation on chip using 2 strains : JIR8094 (CD630E) wild type strain and a ccpA mutant after 6h of growth in TYG. This experimental procedure was designed to investigate the consensus binding site, CRE, of pleiotropic regulator ccpA. Two-conditions experiments, JIR8094 (CD630E) strain 6h vs ccpA mutant 6h, 3 biological replicates for each condition

ORGANISM(S): [Clostridium] difficile

SUBMITTER: Monot Marc 

PROVIDER: E-GEOD-34971 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile.

Antunes Ana A   Camiade Emilie E   Monot Marc M   Courtois Emmanuelle E   Barbut Frédéric F   Sernova Natalia V NV   Rodionov Dmitry A DA   Martin-Verstraete Isabelle I   Dupuy Bruno B  

Nucleic acids research 20120918 21

The catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria. By whole transcriptome analyses, we characterized glucose-dependent and CcpA-dependent gene regulation in Clostridium difficile. About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. The CcpA regulon comprises genes involved in sugar uptake, fermentation  ...[more]

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