A conserved two-component signal transduction system controls the response to phosphate starvation in Bifidobacterium breve UCC2003

ABSTRACT: This work reports on the identification and molecular characterization of a two-component regulatory system (2CRS), encoded by phoRP in Bifidobacterium breve UCC2003, which controls the response to phosphate (Pi) starvation. The response regulator PhoP was shown to bind to the promoter region of pstSCAB, specifying a predicted Pi transporter system, as well as that of phoU, which specifies a putative Pi-responsive regulatory protein. This interaction is assumed to cause transcriptional activation under conditions of Pi limitation. The phoRP genes appear to be subject to positive auto-regulation, and with pstSCAB and phoU, represent the complete regulon controlled by the phoRP-encoded 2CRS in B. breve UCC2003. Determination of the minimal PhoP binding region combined with bioinformatic anal

ORGANISM(S): Bifidobacterium breve UCC2003

SUBMITTER: Aldert Zomer 

PROVIDER: E-GEOD-34983 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress