PPARg agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein

ABSTRACT: Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; however, the underlying mechanisms remain unclear. Here we show that PPARγ ligands require full agonism to induce a brown fat gene program preferentially in subcutaneous white adipose. These effects require expression of PRDM16, a factor that controls the development of classical brown fat. Depletion of PRDM16 blunts the effects of the PPARγ agonist rosiglitazone on the induced brown fat gene program. Conversely, PRDM16 and rosiglitazone synergistically activate the brown fat gene program in vivo. This synergy is tightly associated with an increased accumulation of PRDM16 protein, due in large measure to an increa

ORGANISM(S): Mus musculus

SUBMITTER: Kosaku Shinoda 

PROVIDER: E-GEOD-35011 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress