Gene expression of human skin fibroblast cells derived from hypospadias patients in response to low-dose bisphenol A exposure

ABSTRACT: To better understand the molecular basis of the reproductive health effects of bisphenol A (BPA) on humans, a genome-wide screening was applied to identify novel targets of low-dose bisphenol A exposure in huamn skin fibroblast cells (hSFCs) derived from hypospadias patient children. Three hSFCs were collected at National Research Institute for Child Health and Development, Japan. Gene expression profiles of hSFCs were measured at 24 hours after exposure to 10nM BPA, 0.01nM 17β-estradiol (E2) and 1nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Differentially expressed genes following chemical treatments were identified by unpaired Student’s t test with P values cut off by 0.05 and fold change of more than 1.2 and selected for the network generation and pathway analysis using Ingenuity Path

ORGANISM(S): Homo sapiens

SUBMITTER: akanuma hiromi 

PROVIDER: E-GEOD-35034 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress