Yersinia pseudotuberculosis ymoA mutant vs. wild type YPIII

ABSTRACT: Expression of the virulence regulator RovA of Yersinia pseudotuberculosis, is controlled by the ncRNAs CsrB and CsrC through CsrA and RovM. In this study, we show that the regulator YmoA of the Hha family of nucleoid-associated proteins controls expression of the counterregulated Csr-type RNAs and the Csr-RovM-RovA signalling cascade through alterations of the CsrC RNA stability. YmoA-mediated stabilization of CsrC depends on CsrA and H-NS, but not on the RNA chaperone Hfq and involves a stabilizing stem-loop structure within the 5M-bM-^@M-^Y-region of CsrC. YmoA influence on CsrC stability is complex as YmoA was found to control numerous factors known to affect RNA structures and stability. In addition, YmoA controls temperature-dependent early and later stage virulence genes in an opposi

ORGANISM(S): Yersinia pseudotuberculosis YPIII

SUBMITTER: Ann Heroven 

PROVIDER: E-GEOD-35043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress