MicroRNA expression in thioglycollate and alternatively activated

ABSTRACT: Macrophage activation must be tightly controlled to prevent overzealous responses that cause self-damage. MicroRNAs have been shown to promote classical macrophage activation by blocking concomitant anti-inflammatory signals and transcription factors, but can also place restraints on activation by preventing excessive TLR-signalling. In contrast, the microRNA profile associated with alternatively activated macrophages and their role in regulating wound-healing or anti-helminthic responses has not yet been described. Utilizing an in vivo model of alternative activation, in which adult Brugia malayi nematodes are surgically implanted in the peritoneal cavity of mice, we examined the profile of microRNA expression in these alternatively activated macrophages and compared this to alternatively

ORGANISM(S): Mus musculus

SUBMITTER: Iain Gallagher 

PROVIDER: E-GEOD-35047 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress