MicroRNA implication in murine liver regeneration

ABSTRACT: Liver is uniquely capable to repair itself after injury. Multiple molecular and biochemical processes initiated after partial hepatectomy, lead to proliferation of all cells within the liver. MicroRNAs (miRNAs) are a class of highly abundant non-coding RNA molecules that cause post-transcriptional gene repression and are involved in several biological processes including cell cycle regulation and differentiation. We examined the expression levels of miRNAs in liver tissue received from control mice (L0) and compared them with the corresponding levels in liver tissue 12 hours after liver regeneration induced by 2/3 partial hepatectomy (L12). MicroRNA expression was investigated using microRNA profiling. Further qPCR analysis was used for validation of the differentially expressed microRNAs

ORGANISM(S): Mus musculus

SUBMITTER: Apostolos Zaravinos 

PROVIDER: E-GEOD-35128 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress