Conserved Topological Domains in Mammalian Genomes Identified by High-resolution Analysis of Chromatin Interactions

ABSTRACT: The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is limited. Here we present high-resolution analyses of chromosomal organization in pluripotent and differentiated human and murine cell types determined using the Hi-C technique. We find that the mammalian genome is composed of over 1000 topological domains, which are stable among different cell types and highly conserved across species. These megabase-long genomic structures, defined by prominent local chromatin interactions and separated by narrow boundary regions, likely function to restrict regulatory interactions between cis-acting elements and limit the spreading of heterochromatin during cellular differentiation. Interestingly, the bounda

ORGANISM(S): Mus musculus

SUBMITTER: Feng Yue 

PROVIDER: E-GEOD-35156 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress