Expression profiling of lower-grade diffuse astrocytic glioma

ABSTRACT: Diffuse gliomas represent the most prevalent class of primary brain tumor. Despite significant recent advances in the understanding of glioblastoma (WHO IV), its most malignant subtype, lower-grade (WHO II and III) glioma variants remain comparatively understudied, especially in light of their notably variable clinical behavior. To examine the foundations of this heterogeneity, we performed multidimensional molecular profiling, including global transcriptional analysis, on 101 lower-grade diffuse astrocytic gliomas collected at our own institution, and validated our findings using publically available gene expression and copy number data from large independent patient cohorts. We found that IDH mutational status delineated molecularly and clinically distinct glioma subsets, with IDH mut

ORGANISM(S): Homo sapiens

SUBMITTER: Jason Huse 

PROVIDER: E-GEOD-35158 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress