Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics

ABSTRACT: Burkitt lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL (eBL) in developing countries, necessitating new strategies. The normal germinal center B cell is the presumed cell of origin for both BL and diffuse large B cell lymphoma (DLBCL), yet gene expression analysis suggests that these malignancies may utilize different oncogenic pathways. BL is subdivided into a sporadic subtype (sBL) that is diagnosed in developed countries, the EBV-associated eBL subtype, and an HIV-associated subtype (hivBL), but it is unclear whether these subtypes employ similar or divergent oncogenic mechanisms. Here we used high throughput RNA sequencing and RNA interference screening to discover essential r

ORGANISM(S): Homo sapiens

SUBMITTER: Louis Staudt 

PROVIDER: E-GEOD-35163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress