Gene expression profiles of monocytes derived from chronic lymphocytic leukemia patients and normal controls

ABSTRACT: We collected monocytes from peripheral blood of 5 chronic lymphocytic leukemia (CLL) patients and 5 healthy donors and we performed gene expression analysis by microarray. Comparison of gene expression profiles (GEPs) between CLL-derived and normal monocytes was used to discover molecular abnormalities in this nonmalignant immune cellular population in leukemia-bearing patients. Although analysed cells were not part of the malignant clone, in unsupervised hierarchical clustering analysis, GEPs of normal monocytes were clearly distinguishable from those of monocytes obtained from CLL patients. Supervised analysis identified 65 genes significantly up-regulated and 48 genes down-regulated in CLL monocytes compared with monocytes from normal controls (FC=2, p<0.05). Modification of gene expres

ORGANISM(S): Homo sapiens

SUBMITTER: Rossana Maffei 

PROVIDER: E-GEOD-35179 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress