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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Effects of silencing miR-10b in an U87-2M1 glioma line - an invasive in vivo derived subline of U87 glioma cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Jia Kai Lim

PROVIDER: E-GEOD-35208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme.

Lin J J Teo S S Lam D H DH Jeyaseelan K K Wang S S

Cell death & disease 20121004

Glioblastoma multiforme (GBM) is a heterogeneous disease despite its seemingly uniform pathology. Deconvolution of The Cancer Genome Atlas's GBM gene expression data has unveiled the existence of distinct gene expression signature underlying discrete GBM subtypes. Recent conflicting findings proposed that microRNA (miRNA)-10b exclusively regulates glioma growth or invasion but not both. We showed that silencing of miRNA-10b by baculoviral decoy vectors in a glioma cell line resembling the mesenc ...[more]

PMID: 23034333

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