Synergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis

ABSTRACT: In Burkitt lymphoma (BL), an aggressive germinal-center (GC) derived non-Hodgkin B-cell lymphoma characterized by MYC translocations as early transforming event, the apoptotic properties of MYC must have been overcome by pro-survival signals. Whereas activation of the pro-survival factor NFkappaB is not eminent in BL, PI3K signalling, which mediates B cell receptor associated survival signals in mature B cells, might be the cooperating event. Here we prove this hypothesis by the generation of BL in mice upon concordant expression of MYC and activation of PI3K in GC B cells. Unlike existing murine BL-like models, our tumour model fully phenocopies primary human BL and reflects the complexity of the disease with regard to histological appearance, surface marker expression, and characteristic

ORGANISM(S): Mus musculus

SUBMITTER: Lars Bullinger 

PROVIDER: E-GEOD-35219 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress