Prenatal smoke exposure, DNA methylation, and childhood atopic disorders

ABSTRACT: Background: How prenatal smoke exposure affects DNA methylation leading to atopic disorders remains to be addressed. Epigenetic biomarkers informative of prenatal smoke exposure and atopic disorders are wanting. Since most children suffering from atopic dermatitis (AD) continue to develop asthma later in life, we explored whether prenatal smoke exposure e induces DNA methylation and searched for predictive epigenetic biomarkers for smoke related atopic disorders. Methods: Methylation differences associated with smoke exposure were screened by Illumina methylation panel for children from the Taiwan birth panel study cohort initially. Information about development of atopic dermatitis (AD) and risk factors were collected. Cord blood cotinine levels were measured to represent prenatal smoke

ORGANISM(S): Homo sapiens

SUBMITTER: I-Jen Wang 

PROVIDER: E-GEOD-35222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress